Gums and other stuff

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Qayin
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Gums and other stuff

Post by Qayin » Fri Sep 01, 2017 2:12 pm

hello how are you everyone ? hope your doing great, I have a question what removes pain  when you get a shot into your gums, in your gums and teeth when do for example a root canal is it something to do with the  brain ? GABA receptors or just removes pain in another way if so how, thx please, all the best Qayin

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eye_of_tiger
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Re: Gums and other stuff

Post by eye_of_tiger » Fri Sep 01, 2017 11:57 pm

How does a local anesthetic work?

Two broad classes of pharmacological agents, local and general, can result in anesthesia. Local anesthetics, such as Novocaine, block nerve transmission to pain centers in the central nervous system by binding to and inhibiting the function of an ion channel in the cell membrane of nerve cells known as the sodium channel.

https://www.scientificamerican.com/arti ... esia-work/

This process does not in any way involve GABA (Gamma-Aminobutyric Acid) receptors.

Brian

Qayin
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Re: Gums and other stuff

Post by Qayin » Sat Sep 02, 2017 1:06 am

Thank you, does this all work in the Brain the shot to the gums for no pain when doing for example a root canal ?

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eye_of_tiger
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Re: Gums and other stuff

Post by eye_of_tiger » Sat Sep 02, 2017 11:35 pm

Qayin wrote:
Sat Sep 02, 2017 1:06 am

Thank you, does this all work in the Brain the shot to the gums for no pain when doing for example a root canal ?
It is true that unless the pain signals reach the brain, then you will not feel it.

Local anesthetics only work on the nerves in the local area of the body where they are applied or injected (that is why they are called local), while general anesthetics work upon the entire central nervous system (CNS).

The CNS is made up of the brain and the spinal nerves, where most of the GABA receptors which you were asking about before are to be found.

There are no pain receptors in the brain itself.

A fact which allows surgeons to perform open brain surgery, while the patient is fully conscious and therefore able to provide feedback as to whether the surgeon is getting too close to a vital part of the brain that could be damaged.

Brian

Qayin
Posts: 80
Joined: Wed Sep 17, 2014 8:37 pm

Re: Gums and other stuff

Post by Qayin » Sun Sep 03, 2017 12:12 am

Thank you

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Talia
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Re: Gums and other stuff

Post by Talia » Sun Sep 03, 2017 6:06 pm

Wow, the mystics of root canal uncovered lol. Well done Brian.

:smt005

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